This article originally published in Pharmacological Reports written by Samuel Kohtala
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Introduction
Over the past 50 years, the use of ketamine for anesthesia has become widespread in both human and veterinary medicine. Its safety and short duration and unique mode of action have made ketamine an important drug in emergency medicine and pain management around the world. The study and use of ketamine for the treatment of several new indications, ranging from pain syndromes to drug addiction and psychiatric disorders, is constantly growing. In experimental research, ketamine has unarguably contributed to a better understanding of the glutamatergic system and the development of animal models of schizophrenia [1].
Perhaps the greatest contribution to the legacy of ketamine has been the discovery of its rapid-acting antidepressant effects [2], which has effectively revitalized interest in the development of new antidepressant drugs with a novel mode of action. Indeed, the past decade has seen a rapid increase in the number of research papers associated with ketamine’s antidepressant effects…